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3β-Ursodeoxycholic acid

Name: 3β-Ursodeoxycholic acid
Brand: TargetMol
SKU: T13506
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13506Cas No. 78919-26-3

Alias Isoursodeoxycholic acid

3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid that exhibits good tolerance and good intestinal absorption when administered orally.3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can undergo enzymatic isomerization in the intestines and the 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) undergoes enzymatic isomerization in the intestine and liver and produces UDCA.

3β-Ursodeoxycholic acid

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Purity: 99.89%

Catalog No. T13506Alias Isoursodeoxycholic acidCas No. 78919-26-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$272	In Stock	In Stock
50 mg	$419	In Stock	In Stock
100 mg	$612	-	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid that exhibits good tolerance and good intestinal absorption when administered orally.3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can undergo enzymatic isomerization in the intestines and the 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) undergoes enzymatic isomerization in the intestine and liver and produces UDCA.
In vitro	METHODS: Hep G2 cells were treated with 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) (100 μM) and ethanol (80 μM) to investigate the effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells. The cytotoxic effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells were investigated, as well as the interactions between them. RESULTS 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) did not show any cytotoxic effects and could be cytoprotective against ethanol-induced cell damage. [4] Translated with DeepL.com (free version)
In vivo	METHODS: 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) or UDCA (2.5 g/kg, orally, for 3 weeks) were given to rats , respectively , to compare the metabolism of UDCA and 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) in experimental cholestasis and the effects on cholestasis in rats. RESULTS3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) was completely converted to UDCA in the liver; cholestasis and cholestatic bile acids were identical after intraduodenal administration of either compound. Oral administration of UDCA or 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) significantly improved hepatic biochemistry in chronic cholestasis, but not clinical and histologic parameters. [1] Translated with DeepL.com (free version)
Synonyms	Isoursodeoxycholic acid

Chemical Properties

Molecular Weight	392.57
Formula	C₂₄H₄₀O₄
Cas No.	78919-26-3
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@@H]3O)(C[C@@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]
Relative Density.	1.128 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 135 mg/mL (343.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5473 mL	12.7366 mL	25.4732 mL	127.3658 mL
5 mM	0.5095 mL	2.5473 mL	5.0946 mL	25.4732 mL
10 mM	0.2547 mL	1.2737 mL	2.5473 mL	12.7366 mL
20 mM	0.1274 mL	0.6368 mL	1.2737 mL	6.3683 mL
50 mM	0.0509 mL	0.2547 mL	0.5095 mL	2.5473 mL
100 mM	0.0255 mL	0.1274 mL	0.2547 mL	1.2737 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc